Pueraria Mirifica, a member of the Leguminoseae family, is an herb indigenous to Thailand and has been researched extensively for its beneficial effects in the treatment of menopausal symptoms. Puerarin, the main isoflavone component of Pueraria Mirifica, modulates estrogen receptor expression and could be a safe alternative for the treatment of estrogen dependent conditions. Pueraria also contains the phytoestrogen miroestrol, which functions as a selective estrogen receptor modulator by competitively binding to estrogen and blocking excessive estrogen receptor stimulation. Pueraria root extract has no known side effects and no known drug interactions have been reported. Its beneficial effects on alleviating menopausal symptoms include the reduction of bone loss and hot flashes and the improvement of blood lipid profiles, which could lead to protection from cardiovascular disease. Results of clinical trials have suggested that Pueraria may be a safe alternative to traditional drugs because of its beneficial effects on bone density, genitourinary function and cardiovascular health without the side effects or risks associated with hormone replacement therapy.
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