Promoting Healthy Thyroid Function with Iodine, Bladderwrack, Guggul and Iris
Jill Stansbury
Paul Saunders
David Winston
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Keywords

essential nutrient
iodine
thyroid function
thyroid hormones
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Abstract

Iodine is an essential component of thyroid hormones and is therefore essential for normal thyroid function. However, the therapeutic use of iodine requires careful evaluation because of its narrow range of intake to support optimal thyroid function. The combination of naturally occurring compounds such as Gum Guggul (Commiphora mukul), Blue Flag root (Iris versicolor) and seaweeds such as Bladderwrack (Fucus vesiculosus) has shown beneficial effects in the treatment of thyroid dysfunction. These compounds have different mechanisms of action and may act synergistically to support thyroid health in conditions such as Hashimoto’s disease and subclinical hypothyroidism. Fucus provides iodine and upregulates the production of iodine-processing hormones, while Commiphora enhances the conversion of T4 to T3, and Iris is a detoxifying agent. These three agents have been used in combination with Nettle leaf (Urtica), Ashwagandha (Withania), Triphala, and Bacopa (Bacopa monnieri), and with supplements supporting basal metabolism and general thyroid function such as L-tyrosine, diiodotyrosine, magnesium, selenium, and iron. Reported side effects include the induction of iodine sensitivity by Bladderwrack and hypersensitivity reactions such as rash and pruritis caused by Guggul. The use of Guggul and Iris is not recommended during pregnancy.

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References

Zaragoza MC, Lopez D, Saiz P et al. Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts. J Agric Food Chem 2008; 56(17):7773–80.
Teodoru V, Nicolau GY. Iodine-enriched milk in goiter endemics. Rom J Endocrinol 1992; 30(3-4):165–7.
Lightowler HJ, Davies GJ. Iodine intake and iodine deficiency in vegans as assessed by the duplicate-portion technique and urinary iodine excretion. Br J Nutr 1998; 80(6):529–35.
Lamberg BA. Endemic goitre--iodine deficiency disorders. Ann Med 1991; 23(4):367–72.
Chanoine JP. Selenium and thyroid function in infants, children and adolescents. Biofactors 2003; 19(3-4):137–43.
Kohrle J. Selenium and the control of thyroid hormone metabolism. Thyroid 2005; 15(8):841–53.
Nishiyama S, Mikeda T, Okada T, Nakamura K, Kotani T, Hishinuma A. Transient hypothyroidism or persistent hyperthyrotropinemia in neonates born to mothers with excessive iodine intake. Thyroid 2004; 14(12):1077–83.
Zimmermann M, Delange F. Iodine supplementation of pregnant women in Europe: a review and recommendations. Eur J Clin Nutr 2004; 58(7):979–84.
Yan X, Chuda Y, Suzuki M, Nagata T. Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed. Biosci Biotechnol Biochem 1999; 63(3):605–7.
Jimenez-Escrig A, Jimenez-Jimenez I, Pulido R, Saura-Calixto F. Antioxidant activity of fresh and processed edible seaweeds. J Sci Food Agric 2001; 81(5):530–4.
Deme D, Fimiani E, Pommier J, Nunez J. Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase. Eur J Biochem 1975; 51(2):329–36.
Nagataki S. The average of dietary iodine intake due to the ingestion of seaweeds is 1.2 mg/day in Japan. Thyroid 2008; 18(6):667–8.
Teas J, Pino S, Critchley A, Braverman LE. Variability of iodine content in common commercially available edible seaweeds. Thyroid 2004; 14(10):836–41.
Aksenov DV, Kaplun VV, Tertov VV, Sobenin IA, Orekhov AN. Effect of plant extracts on trans-sialidase activity in human blood plasma. Bull Exp Biol Med 2007; 143(1):46–50.
Noge K, Becerra JX. Germacrene D, a common sesquiterpene in the genus Bursera (Burseraceae). Molecules 2009; 14(12):5289–97.
Tripathi YB, Malhotra OP, Tripathi SN. Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul. Planta Med 1984; 50(1):78–80.
Wu J, Xia C, Meier J, Li S, Hu X, Lala DS. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol 2002; 16(7):1590–7.
Nohr LA, Rasmussen LB, Straand J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther Med 2009; 17(1):16–22.
Wang X, Greilberger J, Ledinski G, Kager G, Paigen B, Jurgens G. The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Atherosclerosis 2004; 172(2):239–46.
Panda S, Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Phytother Res 2005; 19(1):78–80.
Panda S, Kar A. Gugulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Life Sci 1999; 65(12):L137–L141.
Sharma B, Salunke R, Srivastava S, Majumder C, Roy P. Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. Food Chem Toxicol 2009; 47(10):2631–9.
Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA. Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes. J Med Food 2009; 12(4):846–53.
Szapary PO, Wolfe ML, Bloedon LT et al. Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003; 290(6):765–72.
Ulbricht C, Basch E, Szapary P et al. Guggul for hyperlipidemia: a review by the Natural Standard Research Collaboration. Complement Ther Med 2005; 13(4):279–90.

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