Reversing Hypertension with Rauwolfia, Viscum and Piscidia
Jill Stansbury
Paul Saunders
David Winston
Eugene Zampieron
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Keywords

bioactive constituents
hypertension
piscidia
rauwolfia
viscum
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Abstract

Rauwolfia, Viscum, and Psicidia are well known herbs used in the treatment of hypertension. These herbs contain several different bioactive constituents including alkaloids, lectins, rotenones, flavonoids and isoflavones, among others, which research indicates as being cardioprotective, promote vascular health and reduce blood pressure. As the mechanisms of action are different for each herb, due to the varying bioactive compounds present, they can be used alone or in combination for these indications.

Patients being treated with the above-described herbs need to be carefully monitored, particularly for interactions with any concomitant antihypertensive medication—and herbal doses individually tailored.

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References

Baumeister AA, Hawkins MF, Uzelac SM. The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis. J Hist Neurosci 2003; 12(2):207–20.
Fraser HS. Reserpine: A tragic victim of myths, marketing, and fashionable prescribing. Clin Pharmacol Ther 1996; 60(4):368–73.
Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens 2004; 22(1):11–9.
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365(9455):217–23.
Dransfield MT, Rowe SM, Johnson JE, Bailey WC, Gerald LB. Use of beta blockers and the risk of death in hospitalised patients with acute exacerbations of COPD. Thorax 2008; 63(4):301–5.
Huen SC, Goldfarb DS. Adverse metabolic side effects of thiazides: implications for patients with calcium nephrolithiasis. J Urol 2007; 177(4):1238–43.
Steckelings UM, Artuc M, Wollschlager T, Wiehstutz S, Henz BM. Angiotensin-converting enzyme inhibitors as inducers of adverse cutaneous reactions. Acta Derm Venereol 2001; 81(5):321–5.
Takishita S. [Antihypertensive drug therapy: adverse effects and drug interactions]. Nippon Rinsho 2001; 59(5):992–7.
Savory B, Turnbull JH. Luminescence spectra of yohimbine, reserpine and related alkaloids. Journal of Photochemistry 1983; 23(2):171–81.
Smirk FH, McQueen EG. Comparison of rescinnamine and reserpine as hypotensive agents. Lancet 1955; 269(6881):115–16.
Cronheim G, Brown W, Cawthrone J, Toekes MI, Ungari J. Pharmacological studies with rescinnamine, a new alkaloid isolated from Rauwolfia serpentina. Proc Soc Exp Biol Med 1954; 86(1):120–4.
Fife R, MacLaurin JC, Wright JH. Rescinnamine in treatment of hypertension in hospital clinic and in general practice. Br Med J 1960; 2(5216):1848–50.
Moyer JH, Dennis E, Ford R. Drug therapy (Rauwolfia) of hypertension. II. A comparative study of different extracts of Rauwolfia when each is used alone (orally) for therapy of ambulatory patients with hypertension. AMA Arch Intern Med 1955; 96(4):530–43.
Billow BW, Spector R, Martorella FJ, Paley SS, Harris SB. The effect of a new Rauwolfia derivative, deserpidine, in hypertension. N Y State J Med 1958; 58(22):3641–2.
Moyer JH, Kinard SA, Herschberger R, Dennis EW. Deserpidine (canescine) for the treatment of hypertension. South Med J 1957; 50(4):499–502.
Cromwell HA. Control of hypertension with hydrochlorothiazide and deserpidine. Med Times 1961; 89:801–6.
Kossover MF, Goldman AM. A combination of methyclothiazide and deserpidine in the treatment of essential hypertension. Dis Chest 1962; 42:170–5.
Brugada R, Brugada J, Antzelevitch C et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation 2000; 101(5):510–5.
Rolf S, Bruns HJ, Wichter T et al. The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol. Eur Heart J 2003; 24(12):1104–12.
Jerie P. [Milestones of cardiovascular therapy. IV. Reserpine]. Cas Lek Cesk 2007; 146(7):573–7.
Shamon SD, Perez MI. Blood pressure lowering efficacy of reserpine for primary hypertension. Cochrane Database Syst Rev 2009;(4):CD007655.
Liu LS, Chen MQ, Zeng GY, Zhou BF. [A forty-year study on hypertension]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2002; 24(4):401–8.
Mart’ianova TA, Seryi EI, Alekseev PA, Bykova LR. [Effect of hypotensive therapy on oxygen metabolism in middle-aged and elderly hypertensive patients]. Kardiologiia 1981; 21(3):56–60.
Fahim M, Khan MS, Hameed HA. Effect of Ajmaloon on the baroreceptor-heart rate reflex in anaesthetized rabbits and monkeys. Indian J Physiol Pharmacol 1995; 39(2):101–5.
Lundberg JM, Rudehill A, Sollevi A, Theodorsson-Norheim E, Hamberger B. Frequency- and reserpine-dependent chemical coding of sympathetic transmission: differential release of noradrenaline and neuropeptide Y from pig spleen. Neurosci Lett 1986; 63(1):96–100.
Deliorman D, Calis I, Ergun F, Dogan BS, Buharalioglu CK, Kanzik I. Studies on the vascular effects of the fractions and phenolic compounds isolated from Viscum album ssp album. J Ethnopharmacol 2000; 72(1-2):323–9.
Rodriguez-Cruz ME, Perez-Ordaz L, Serrato-Barajas BE, Juarez-Oropeza MA, Mascher D, Paredes-Carbajal MC. Endothelium-dependent effects of the ethanolic extract of the mistletoe Psittacanthus calyculatus on the vasomotor responses of rat aortic rings. J Ethnopharmacol 2003; 86(2-3):213–8.
Mojiminiyi FB, Owolabi ME, Igbokwe UV, Ajagbonna OP. The vasorelaxant effect of Viscum album leaf extract is mediated by calcium-dependent mechanism. Niger J Physiol Sci 2008; 23(1-2):115–20.
Radenkovic M, Ivetic V, Popovic M, Brankovic S, Gvozdenovic L. Effects of mistletoe (Viscum album L., Loranthaceae) extracts on arterial blood pressure in rats treated with atropine sulfate and hexocycline. Clin Exp Hypertens 2009; 31(1):11–9.
Ofem OE, Eno AE, Nku CO, Antai AB. Viscum album (mistletoe) extract prevents changes in levels of red blood cells, PCV, Hb, serum proteins and ESR in high salt-fed rats. J Ethnopharmacol 2009; 126(3):421–6.
Gorudko IV, Buko IV, Cherenkevich SN, Polonetsky LZ, Timoshenko AV. Lectin-induced aggregates of blood cells from patients with acute coronary syndromes. Arch Med Res 2008; 39(7):674–81.
Chu W, Qiao G, Bai Y et al. Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. Phytother Res 2008; 22(1):134–7.
Ellingwood F. The American Materia Medica, Therapeutics and Pharmacognosy. 1919.
Blatt CT, Chavez D, Chai H et al. Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis. Phytother Res 2002; 16(4):320–5.
Jang DS, Park EJ, Kang YH et al. Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria. J Nat Prod 2003; 66(9):1166–70.
Della LR, Zilli C, Del NP, Redaelli C, Tubaro A. Isoflavones as spasmolytic principles of Piscidia erythrina. Prog Clin Biol Res 1988; 280:365–8.
Della LR, Tubaro A, Redaelli C. [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. Riv Neurol 1981; 51(5):297–310.

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