Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease
Jill Stansbury
Paul Saunders
David Winston
Eugene Zampieron
PDF
HTML

Keywords

autoimmune diseases
inflammation
Rosmarinic acid
t cell apoptosis
PDF
HTML

Abstract

Rosmarinic acid has been shown to selectively induce T cell apoptosis in aberrant lymphocytes, but not normal/quiescent T cells. Rosmarinic acid also reduces gamma interferon driven T cell responses and reduces interleukin production following T cell stimulation. Furthermore, rosmarinic acid affects signal transduction inside T cells by affecting specific tyrosine kinase enzymes inside the cell. By direct effects on T cells as well as other anti-inflammatory and antioxidant effects, rosmarinic acid may be a safe and valuable tool for reducing autoimmune inflammation. It may also be safe and advantageous to use in tandem with pharmaceutical treatment of autoimmune diseases.

PDF
HTML

References

Ibarra A, Cases J, Bily A et al. Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. J Med Food 2010; 13(5):1167–75.
Fang L, Lin N, Wu Y. [Simultaneous determination of four active components in Spica Prunellae by HPLC]. Zhongguo Zhong Yao Za Zhi 2010; 35(5):616–9.
Weitzel C, Petersen M. Enzymes of phenylpropanoid metabolism in the important medicinal plant Melissa officinalis L. Planta 2010; 232(3):731–42.
Petersen M, Abdullah Y, Benner J et al. Evolution of rosmarinic acid biosynthesis. Phytochemistry 2009; 70(15-16):1663–79.
Ben FM, Jordan MJ, Chaouech-Hamada R, Landoulsi A, Sotomayor JA. Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L. J Agric Food Chem 2009; 57(21):10349–56.
Yamamoto H, Inoue K, Yazaki K. Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures. Phytochemistry 2000; 53(6):651–7.
Moreno S, Scheyer T, Romano CS, Vojnov AA. Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic Res 2006; 40(2):223–31.
Jung dY, Kim EY, Joo SY et al. Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody. Exp Mol Med 2008; 40(1):1–10.
Auf’mkolk M, Amir SM, Kubota K, Ingbar SH. The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. Endocrinology 1985; 116(5):1677–86.
Hur YG, Suh CH, Kim S, Won J. Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway. J Clin Immunol 2007; 27(1):36–45.
Park SH, Oh HS, Kang MA et al. The structure-activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain. Bioorg Med Chem 2007; 15(11):3938–50.
Kang MA, Yun SY, Won J. Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity. Blood 2003; 101(9):3534–42.
Won J, Hur YG, Hur EM et al. Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner. Eur J Immunol 2003; 33(4):870–9.
Hur YG, Yun Y, Won J. Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. J Immunol 2004; 172(1):79–87.
Paccani SR, Boncristiano M, Ulivieri C, D’Elios MM, Del PG, Baldari CT. Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p38 MAPK induction. J Biol Chem 2002; 277(2):1509–13.
Youn J, Lee KH, Won J et al. Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis. J Rheumatol 2003; 30(6):1203–7.
Yun SY, Hur YG, Kang MA, Lee J, Ahn C, Won J. Synergistic immunosuppressive effects of rosmarinic acid and rapamycin in vitro and in vivo. Transplantation 2003; 75(10):1758–60

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 4.0). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.