Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease
Jill Stansbury
Paul Saunders
David Winston
Eugene Zampieron


autoimmune diseases
Rosmarinic acid
t cell apoptosis


Rosmarinic acid has been shown to selectively induce T cell apoptosis in aberrant lymphocytes, but not normal/quiescent T cells. Rosmarinic acid also reduces gamma interferon driven T cell responses and reduces interleukin production following T cell stimulation. Furthermore, rosmarinic acid affects signal transduction inside T cells by affecting specific tyrosine kinase enzymes inside the cell. By direct effects on T cells as well as other anti-inflammatory and antioxidant effects, rosmarinic acid may be a safe and valuable tool for reducing autoimmune inflammation. It may also be safe and advantageous to use in tandem with pharmaceutical treatment of autoimmune diseases.



Ibarra A, Cases J, Bily A et al. Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. J Med Food 2010; 13(5):1167–75.
Fang L, Lin N, Wu Y. [Simultaneous determination of four active components in Spica Prunellae by HPLC]. Zhongguo Zhong Yao Za Zhi 2010; 35(5):616–9.
Weitzel C, Petersen M. Enzymes of phenylpropanoid metabolism in the important medicinal plant Melissa officinalis L. Planta 2010; 232(3):731–42.
Petersen M, Abdullah Y, Benner J et al. Evolution of rosmarinic acid biosynthesis. Phytochemistry 2009; 70(15-16):1663–79.
Ben FM, Jordan MJ, Chaouech-Hamada R, Landoulsi A, Sotomayor JA. Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L. J Agric Food Chem 2009; 57(21):10349–56.
Yamamoto H, Inoue K, Yazaki K. Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures. Phytochemistry 2000; 53(6):651–7.
Moreno S, Scheyer T, Romano CS, Vojnov AA. Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic Res 2006; 40(2):223–31.
Jung dY, Kim EY, Joo SY et al. Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody. Exp Mol Med 2008; 40(1):1–10.
Auf’mkolk M, Amir SM, Kubota K, Ingbar SH. The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. Endocrinology 1985; 116(5):1677–86.
Hur YG, Suh CH, Kim S, Won J. Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway. J Clin Immunol 2007; 27(1):36–45.
Park SH, Oh HS, Kang MA et al. The structure-activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain. Bioorg Med Chem 2007; 15(11):3938–50.
Kang MA, Yun SY, Won J. Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity. Blood 2003; 101(9):3534–42.
Won J, Hur YG, Hur EM et al. Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner. Eur J Immunol 2003; 33(4):870–9.
Hur YG, Yun Y, Won J. Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. J Immunol 2004; 172(1):79–87.
Paccani SR, Boncristiano M, Ulivieri C, D’Elios MM, Del PG, Baldari CT. Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p38 MAPK induction. J Biol Chem 2002; 277(2):1509–13.
Youn J, Lee KH, Won J et al. Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis. J Rheumatol 2003; 30(6):1203–7.
Yun SY, Hur YG, Kang MA, Lee J, Ahn C, Won J. Synergistic immunosuppressive effects of rosmarinic acid and rapamycin in vitro and in vivo. Transplantation 2003; 75(10):1758–60

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