Maher B. Personal genomes: The case of the missing heritability. Nature. 2008 Nov 6; 456(7218):18–21.
Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci. 2010 Nov; 1212:59–77.
Kussmann M, Krause L, Siffert W. Nutrigenomics: where are we with genetic and epigenetic markers for disposition and susceptibility? Nutr Rev. 2010 Nov; 68Suppl 1:S38–47
Kaati G, Bygren LO, Pembrey M, et al. Transgenerational response to nutrition, early life circumstances and longevity. Eur J Hum Genet. 2007 Jul; 15(7):784–90.
Pembrey ME. Male-line transgenerational responses in humans. Hum Fertil (Camb). 2010 Dec; 13(4):268–71.
Szyf M, McGowan P, Meaney MJ. The social environment and the epigenome. Environ Mol Mutagen. 2008 Jan; 49(1):46–60.
Armitage JA, Taylor PD, Poston L. Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J Physiol. 2005 May 15; 565(Pt 1):3–8.
Gluckman PD, Hanson MA, Beedle AS. Early life events and their consequences for later disease: a life history and evolutionary perspective.Am J Hum Biol. 2007 Jan-Feb; 19(1):1–19.
Porta M, Puigdomenech E, Ballester F, et al. Monitoring concentrations of persistent organic pollutants in the general population: the international experience. Environ Int. 2008; 34(4):546–561.
Lee DH, Lee IK, Song K, et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 Jul; 29(7):1638–44.
Ukropec J, Radikova Z, Huckova M, et al. High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail. Diabetologia. 2010 May; 53(5):899–906.
Lee DH, Steffes MW, Sjödin A, et al. Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes. PLoS One. 2011 Jan 26; 6(1):e15977.
Lim S, Ahn SY, Song IC, et al. Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance. PLoS One. 2009; 4(4):e5186.
Lee HK. Mitochondrial dysfunction and insulin resistance: the contribution of dioxin-like substances. Diabetes Metab J. 2011 Jun; 35(3):207–15.
Lee DH, Lee IK, Jin SH, et al. Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999–2002. Diabetes Care. 2007 Mar; 30(3):622–8.
Kim KS, Hong NS, Jacobs DR Jret al. Interaction Between Persistent Organic Pollutants and C-reactive Protein in Estimating Insulin Resistance Among Non-diabetic Adults. J Prev Med Public Health. 2012 Mar; 45(2):62–9.
Vandenberg LN, Colborn T, Hayes TB, et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012 Jun; 33(3):378–455.
Ha M.H, Lee D.H, et al. Association between serum concentrations of persistent organic pollutants and self-reported cardiovascular disease prevalence: results from the National Health and Nutrition Examination Survey, 1999–2002. Environ Health Perspect. 115 ( 2007), pp. 1204–1209
Ha M.H, Lee D.H, et al. Association between serum concentrations of persistent organic pollutants and prevalence of newly diagnosed hypertension: results from the National Health and Nutrition Examination Survey 1999–2002. J Hum Hypertens. 23 2009, pp. 274–286
Min JY, Cho JS, Lee KJ, et al. Potential role for organochlorine pesticides in the prevalence of peripheral arterial diseases in obese persons: results from the National Health and Nutrition Examination Survey 1999–2004. Atherosclerosis. 2011 Sep; 218(1):200–6.
Lind PM, van Bavel B, Salihovic S, et al. Circulating levels of persistent organic pollutants (POPs) and carotid atherosclerosis in the elderly.Environ Health Perspect. 2012 Jan; 120(1):38–43.
Lind PM, Lind L. Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly. Atherosclerosis. 2011 Sep; 218(1):207–13.
Bouchard MF, Chevrier J, Harley KG, et al. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ Health Perspect. 2011 Aug; 119(8):1189–95.
Rauh V, Arunajadai S, Horton M, et al. Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ Health Perspect. 2011 Aug; 119(8):1196–201.
Bouchard MF, Bellinger DC, Wright RO, et al. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides.Pediatrics. 2010 Jun; 125(6):e1270–7.
Rauh VA, Perera FP, Horton MK, et al. Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7871–6.
Engel SM, Wetmur J, Chen J, et al. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect. 2011 Aug; 119(8):1182–8.
Gascon M, Vrijheid M, Martínez D, et al. Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age. Environ Int. 2011 Apr; 37(3):605–11.
Herbstman JB, Sjödin A, Kurzon M, et al. Prenatal exposure to PBDEs and neurodevelopment. Environ Health Perspect. 2010 May; 118(5):712–9.
Eskenazi B, Chevrier J, Rauch SA, et al. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS Study. Environ Health Perspect. 2013; 121(2):257–62.
Hoffman K, Webster TF, Weisskopf MG, et al. Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12–15 years of age. Environ Health Perspect. 2010 Dec; 118(12):1762–7.
Engel SM, Miodovnik A, Canfield RL, et al. Prenatal phthalate exposure is associated with childhood behavior and executive functioning.Environ Health Perspect. 2010 Apr; 118(4):565–71.
Whyatt RM, Liu X, Rauh VA, et al. Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age. Environ Health Perspect. 2012 Feb; 120(2):290–5.
Manthripragada AD, Costello S, Cockburn MG, et al. Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease.Epidemiology. 2010 Jan; 21(1):87–94.
van der Mark M, Brouwer M, Kromhout H, et al. Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results.Environ Health Perspect. 2012 Mar; 120(3):340–7.
Malek AM, Barchowsky A, Bowser R, et al. Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: a meta-analysis of epidemiological studies: pesticide exposure as a risk factor for ALS. Environ Res. 2012 Aug; 117:112–9.
Kamel F, Umbach DM, Bedlack RS, et al. Pesticide exposure and amyotrophic lateral sclerosis. Neurotoxicology. 2012 Jun; 33(3):457–62.
Dewailly E, Mulvad G, Pedersen HS, et al. Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland. Environ Health Perspect. 1999 Oct; 107(10):823–828.
Rusiecki JA, Baccarelli A, Bollati V, et al. Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect. 2008 Nov; 116(11):1547–52.
Ehrlich M. Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol. 2006; 310:251–74.
Goelz SE, Vogelstein B, Hamilton SR, et al. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science. 1985; 228:187–90.
Kim KY, Kim DS, Lee SK, et al. Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans. Environ Health Perspect. 2010 Mar; 118(3):370–4.
Wilson AS, Power BE, Molloy PL. DNA hypomethylation and human diseases. Biochim Biophys Acta. 2007; 1775(1):138–162.
Friso S, Udali S, Guarini P, et al. Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiol Biomarkers Prev. 2013; 22:348–55.
Godderis L, De Raedt K, Tabish AM, et al. Epigenetic changes in lymphocytes of solvent-exposed individuals. Epigenomics. 2012 Jun; 4(3):269–77.
Lee DH, Jacobs DR Jr, Porta M. Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of DNA hypomethylation.Environ Health Perspect. 2009 Dec; 117(12):1799–802.
Toperoff G, Aran D, Kark JD, et al. Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet. 2012 Jan 15; 21(2):371–83.
Yang BT, Dayeh TA, Volkov PA, et al. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol. 2012 Jul; 26(7):1203–12.
Godfrey KM, Sheppard A, Gluckman PD, et al. Epigenetic gene promoter methylation at birth is associated with child’s later adiposity.Diabetes. 2011 May; 60(5):1528–34.
Lind PM, Roos V, Rönn M, et al. Serum concentrations of phthalate metabolites related to abdominal fat distribution two years later in elderly women. Environ Health. 2012 Apr 2; 11(1):21.
Teitelbaum SL, Mervish N, Moshier EL, et al. Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environ Res. 2012 Jan; 112:186–93.
Lind PM, Zethelius B, Lind L. Circulating Levels of Phthalate Metabolites Are Associated With Prevalent Diabetes in the Elderly. Diabetes Care. 2012 Jul; 35(7):1519–24.
Movassagh M, Vujic A, Foo R. Genome-wide DNA methylation in human heart failure. Epigenomics. 2011 Feb; 3(1):103–9.
Wagner C, Koury MJ. S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine? Am J Clin Nutr. 2007 Dec; 86(6):1581–5.
Baccarelli A, Ghosh S. Environmental exposures, epigenetics and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):323–9.
Castro R, Rivera I, Struys EA, et al. Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem. 2003 Aug; 49(8):1292–6.
Song C, Kanthasamy A, Anantharam V, et al. Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration. Mol Pharmacol 2010; 77:621–32.
Kundakovic M, Champagne FA. Epigenetic perspective on the developmental effects of bisphenol A. Brain Behav Immun. 2011 Aug; 25(6):1084–93.
Wolstenholme JT, Rissman EF, Connelly JJ. The role of Bisphenol A in shaping the brain, epigenome and behavior. Horm Behav. 2011 Mar; 59(3):296–305.
Spanier AJ, Kahn RS, Kunselman AR, et al. Prenatal exposure to bisphenol a and child wheeze from birth to 3 years of age. Environ Health Perspect. 2012 Jun; 120(6):916–20.
Braun JM, Kalkbrenner AE, Calafat AM, et al. Impact of early-life bisphenol A exposure on behavior and executive function in children.Pediatrics. 2011 Nov; 128(5):873–82.
Chou WC, Chen JL, Lin CF, et al. Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan. Environ Health. 2011 Nov 3; 10:94
James SJ, Melnyk S, Jernigan S, et al. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord. 2008 Nov; 38(10):1966–75.
Melnyk S, Fuchs GJ, Schulz Eet al. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disord. 2012 Mar; 42(3):367–77.
Mitchell MM, Woods R, Chi LHet al. Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ Mol Mutagen. 2012 Oct; 53(8):589–98.
Woods R, Vallero RO, Golub MS, et al. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet. 2012 Jun 1; 21(11):2399–411.
Gore AC, Walker DM, Zama AM, et al. Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive aging. Mol Endocrinol. 2011 Dec; 25(12):2157–68.
Cortessis VK, Thomas DC, Levine AJ, et al. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012 Oct; 131(10):1565–89.
Salam MT, Byun HM, Lurmann F, et al. Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children. J Allergy Clin Immunol. 2012 Jan; 129(1):232–9.e1–7.
Wallace DC. Bioenergetics and the epigenome: interface between the environment and genes in common diseases. Dev Disabil Res Rev. 2010 Jun; 16(2):114–19.
Curl CL, Fenske RA, Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ Health Perspect. 2003 Mar; 111(3):377–82.
Lu C, Barr DB, Pearson MA, et al. Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children. Environ Health Perspect. 2008 Apr; 116(4):537–42.
Barrès R, Yan J, Egan Bet al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 7; 15(3):405–11.
Pizzorno, J, Katzinger, J. Glutathione: Physiological and Clinical Relevance. Journal of Restorative Medicine 2012; 1:24–37.
LaSalle JM. A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics. 2011 Jul; 6(7):862–9.
Baccarelli A, Cassano PA, Litonjua Aet al. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008 Apr 8; 117(14):1802–9.