Dhillon N, Aggarwal BB, Newman RA, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 2008; 14(14):4491–9.
Dhanasekaran M, Baskar AA, Ignacimuthu S, Agastian P, Duraipandiyan V. Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. Invest New Drug. 2009; 27(4):347–55.
Krishnaveni M, Mirunalini S. Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharmacol. 2010; 21(1):93–105.
Krithika R, Verma RJ. Mitigation of carbon tetrachloride-induced damage by Phyllanthus amarus in liver of mice. Acta Pol Pharm. 2009; 66(4):439–44.
Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol. 1993; 40(3):155–61.
Singh B, Saxena AK, Chandan BK, Agarwal SG, Anand KK. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol. 2001; 45(4):435–41.
Chakraborty D, Verma R. Ameliorative effect of Emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the kidney and liver of mice. Int J Occup Med Environ Health. 2010; 23(1):63–73.
Reddy VD, Padmavathi P, Varadacharyulu N. Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats. J Med Food. 2009; 12(2):327–33.
Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res: PTR. 2010; 24(10):1423–32.
Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther. 2010; 332(3):1081–7.
Polyak SJ, Morishima C, Lohmann V, et al. Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci USA. 2010; 107(13):5995–9.
Shaker E, Mahmoud H, Mnaa S. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol. 2010; 48(3):803–6.
Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementarmed. (2006). 2008; 15(1):9–20.
Hawke RL, Schrieber SJ, Soule TA, et al. Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol. 2010; 50(4):434–449.
Cheung CW, Gibbons N, Johnson DW, Nicol DL. Silibinin—a promising new treatment for cancer. Anti Can Agents Med Chem. 2010; 10(3):186–95.
Aghazadeh S, Amini R, Yazdanparast R, Ghaffari SH. Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. Exp Toxicol Pathol. 2011; 63(6):569–74.
Grizzle J, Hadley TL, Rotstein DS, et al. Effects of dietary milk thistle on blood parameters, liver pathology, and hepatobiliary scintigraphy in white carneaux pigeons (Columba livia) challenged with B1 aflatoxin. J Avian Med Surg. 2009; 23(2):114–24.
Tsai JH, Liu JY, Wu TT, et al. Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat. 2008; 15(7):508–14.
Morishima C, Shuhart MC, Wang CC, et al. Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.Gastroenterology. 2010; 138(2):671–81, 681 e671–2 .
Gharagozloo M, Moayedi B, Zakerinia M, et al. Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial. Fund Clin Pharmacol. 2009; 23(3):359–65.
El-Kamary SS, Shardell MD, Abdel-Hamid M, et al. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine. 2009; 16(5):391–400.
Bao W, Li K, Rong S, et al. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol. 2010; 128(2):549–53.
Bengmark S, Mesa MD, Gil A. Plant-derived health: the effects of turmeric and curcuminoids. Nutr Hosp. 2009; 24(3):273–81.
Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008; 114(2):127–49.
Weerachayaphorn J, Chuncharunee A, Jariyawat S, et al. Protection of centrilobular necrosis by Curcuma comosa Roxb. in carbon tetrachloride-induced mice liver injury. J Ethnopharmacol. 2010; 129(2):254–60.
Wu SJ, Tam KW, Tsai YH, Chang CC, Chao JC. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.Am J Chin Med. 2010; 38(1):99–111.
Wang SY, Xue J, Zhou J. [Preliminary effects of alcohol and Curcuma longa upon CYP2E1 and hematotoxicity in benzene-induced mice].Zhonghua yi xue za zhi. 2009; 89(34):2429–31.
Nayak S, Sashidhar RB. Metabolic intervention of aflatoxin B1 toxicity by curcumin. J Ethnopharmacol. 2010; 127(3):641–4.
Yarru LP, Settivari RS, Gowda NK, Antoniou E, Ledoux DR, Rottinghaus GE. Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin. Poultry Sci. 2009; 88(12):2620–7.
Kheradpezhouh E, Panjehshahin MR, Miri R, et al. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. Eur J Pharmaco. 2010; 628(1–3):274–81.
Rivera-Espinoza Y, Muriel P. Pharmacological actions of curcumin in liver diseases or damage. Liver Int. 2009; 29(10):1457–66.
Mohamad RH, El-Bastawesy AM, Zekry ZK, et al. The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats. J Med Food. 2009; 12(2):394–402.
Kim HJ, Yoo HS, Kim JC, et al. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. J Ethnopharmacol. 2009; 124(2):189–96.
Priya S, Sudhakaran PR. Curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells.Indian J Biochem Biophys. 2008; 45(5):317–25.
Shoba G, Joy D, Joseph T, et.al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998; 64(4):353–56.
Cuomo J. Appendino G., Dern AS, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod. 2011; 74(4):664–9.
Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010; 62(7):919–30.
Li W, Liu Z, Wang Z, et al. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J Sep Sci. 2010; 33(12):1870–6.
Abe H, Sakaguchi M, Odashima S, Arichi S. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat. Naunyn-Schmiedebergs Arch Pharmacol. 1982; 320(3):266–71.
Fan J, Li X, Li P, et al. Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol. 2007; 85(2):189–95.
Wohlfarth C, Efferth T. Natural products as promising drug candidates for the treatment of hepatitis B and C. Acta Pharm Sinic. 2009; 30(1):25–30.
Chiang LC, Ng LT, Liu LT, Shieh DE, Lin CC. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species. Planta Med. 2003; 69(8):705–9.
Hsu YL, Kuo PL, Chiang LC, Lin CC. Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines. Cancer Lett. 2004; 213(2):213–21.
Nagarkatti DS, Rege NN, Desai NK, Dahanukar SA. Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. J Postgrad Med. 1994; 40(2):65–7.
Reddy SS, Ramatholisamma P, Ramesh B, Baskar R, Saralakumari D. Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in Wistar rats. Horm Metab Res. 2009; 41(10):741–6.
Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol Sci. 2002; 27(3):139–46.
Adhvaryu MR, Reddy N, Parabia MH. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. World J Gastroenterol. 2007; 13(23):3199–205.
Panchabhai TS, Ambarkhane SV, Joshi AS, Samant BD, Rege NN. Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study. Phytother Res. 2008; 22(5):646–50.
Rege N, Bapat RD, Koti R, Desai NK, Dahanukar S. Immunotherapy with Tinospora cordifolia: a new lead in the management of obstructive jaundice. Indian J Gastroenterol. 1993; 12(1):5–8.
Mironova GD, Shigaeva MI, Belosludtseva NV, et al. Effect of several flavonoid-containing plant preparations on activity of mitochondrial ATP-dependent potassium channel. Bull Exp Biol Med. 2008; 146(2):229–33.
Sharma A, Sharma MK, Kumar M. Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice. Chem-Biol Interact. 2009; 180(1):20–30.
Chen TS, Liou SY, Chang YL. Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients. Am J Chinese Med. 2009; 37(1):19–25.
Verma R, Chakraborty D. Alterations in DNA, RNA and protein contents in liver and kidney of mice treated with ochratoxin and their amelioration by Emblica officinalis aqueous extract. Acta Pol Pharm. 2008; 65(1):3–9.
Sultana S, Ahmed S, Jahangir T. Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats. J Ethnopharmacol. 2008; 118(1):1–6.
Anilakumar KR, Nagaraj NS, Santhanam K. Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn. Indian J Exp Biol. 2007; 45(5):450–4.
Reddy VD, Padmavathi, P, Gopi, S, et.al. Protective effect of emblica officinalis against alcohol-induced hepatic injury by ameliorating oxidative stress in rats. Indian J Clin Biochem. 2010; 25(4):419–24.
Shivananjappa MM, Joshi MK. Influence of emblica officinalis aqueous extract on growth and antioxidant defense systems of human hepatoma cell line (HepG2). Pharm Biol. 2012; 50(4):497–505.
Yokozawa T, Kim HY, Kim HJ, Okubo T, Chu DC, Juneja LR. Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process. Br J Nutr. 2007; 97(6):1187–95.
Böckmann E, Köppler K, Hummel E, Vogt H. Bait spray for control of European cherry fruit fly—an appraisal based on semi-field and field studies. Pest Manag Sci. 2013, in press, doi: 10.1002/ps.3621 .
McKenna MM, Hammad EM, Farran MT. Effect of Melia azedarach (Sapindales: Meliaceae) fruit extracts on Citrus Leafminer Phyllocnistis citrella (Lepidoptera: Gracillariidae). SpringerPlus. 2013; 2(1):144–50.
Luong K, Dunkel FV, Coulibaly K, Beckage NE. Potential use of neem leaf slurry as a sustainable dry season management strategy to control the malaria vector Anopheles gambiae (DIPTERA: CULICIDAE) in west African villages. J Med Entomol. 2012; 49(6):1361–9.
Raveendra A, Ampasala DR, Sandhya D, Thyagaraju K. Oral administration of Azadirachta indica (L.) seed kernel active principle protects rat liver hepatocytes and testis seminiferous tubules from phenobarbitol-induced damage. J Herbal Pharmacotherapy. 2007; 7(3–4):259–66.
Koul A, Binepal G, Gangar SC. Impediment of diethylnitrosamine induced hepatotoxicity in male Balb/c mice by pretreatment with aqueous Azadirachta indica leaf extract. Indian J Exp Biol. 2007; 45(4):359–66.
Vinothini G, Manikandan P, Anandan R, Nagini S. Chemoprevention of rat mammary carcinogenesis by Azadirachta indica leaf fractions: modulation of hormone status, xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation and apoptosis. Food Chem Toxicol. 2009; 47(8):1852–63.
Haque E, Mandal I, Pal S, Baral R. Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. Immunopharm Immunot. 2006; 28(1):33–50.
Subapriya R, Nagini S. Medicinal properties of neem leaves: a review. Curr Med Chem Anticancer Agents. 2005; 5(2):149–6.
Sharma V, Walia S, Kumar J, Nair MG, Parmar BS. An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS. J Agric Food Chem. 2003; 51(14):3966–72.
Ricci F, Berardi V, Risuleo G. Differential cytotoxicity of MEX: a component of Neem oil whose action is exerted at the cell membrane level.Molecules. 2008; 14(1):122–32.
Moursi SK, Abo-Shanab AS, Mesbah HA, Abdel-Razak SI, Mourad AK, Zaghloul OA, Abdel-Fatah RS. Efficacy of some oils and chemical compounds on Insignorthezia insignis (Browne) (Hemiptera: Ortheziidae) infesting Lantana camara in Alexandria, Egypt. Commun Agric Appl Biol Sci. 2010; 75(3):345–57.
Longo L, Platini F, Scardino A, Alabiso O, Vasapollo G, Tessitore L. Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma. Mol Cancer Ther. 2008; 7(8):2476–85.
Rao GM, Rao CV, Pushpangadan P, Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006; 103(3):484–90.
Marczylo T, Arimoto-Kobayashi S, Hayatsu H. Protection against Trp-P-2 mutagenicity by purpurin: mechanism of in vitro antimutagenesis.Mutagenesis. 2000; 15(3):223–8.
Ho LK, Don MJ, Chen HC, Yeh SF, Chen JM. Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia. J Nat Prod. 1996; 59(3):330–3.
Inoue K, Yoshida M, Takahashi M, et al. Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay. Cancer Sci. 2009; 100(12):2261–7.
Inoue K, Yoshida M, Takahashi M, et al. Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study. Food Chem Toxicol. 2009; 47(1):184–91.
Inoue K, Shibutani M, Masutomi N, et al. A 13-week subchronic toxicity study of madder color in F344 rats. Food Chem Toxicol. 2008; 46(1):241–52.
Maiti K, Mukherjee K, Murugan V, Saha BP, Mukherjee PK. Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome. J Sci Food Agr. 2010; 90(1):43–51.
Tripathi R, Kamat JP. Free radical induced damages to rat liver subcellular organelles: inhibition by Andrographis paniculata extract. Indian J Exp Biol. 2007; 45(11):959–67.
Trivedi NP, Rawal UM, Patel BP. Potency of andrographolide as an antitumor compound in BHC-induced liver damage. Integr Cancer Ther. 2009; 8(2):177–89.
Roy DN, Mandal S, Sen G, Mukhopadhyay S, Biswas T. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010; 160(7):1823–43.
Yang L, Wu D, Luo K, Wu S, Wu P. Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer Lett. 2009; 276(2):180–8.
Chang KT, Lii CK, Tsai CW, Yang AJ, Chen HW. Modulation of the expression of the pi class of glutathione S-transferase by Andrographis paniculata extracts and andrographolide. Food Chem Toxicol. 2008; 46(3):1079–88.
McClain CJ, Price S, Barve S, Devalarja R, Shedlofsky S. Acetaminophen hepatotoxicity: An update. Curr Gastroenterol Rep. 1999; 1(1):42–9.
Trivedi NP, Rawal UM, Patel BP. Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury. Integr Cancer Ther. 2007; 6(3):271–80.
Sheeja K, Kuttan G. Ameliorating effects of Andrographis paniculata extract against cyclophosphamide-induced toxicity in mice. Asian Pac J Cancer Prev. 2006; 7(4):609–14.
Sangameswaran B, Reddy TC, Jayakar B. Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. Phytother Res. 2008; 22(1):124–6.