Jackson MP, Hewitt EW. Cellular proteostasis: degradation of misfolded proteins by lysosomes. Essays Biochem. 2016; 60:173–80.
Wang B, Abraham N, Gao G, Yang Q. Dysregulation of autophagy and mitochondrial dysfunction in Parkinson’s disease. Transl Neurodegener. 2016; 5:19.
Castellani RJ, Zhu X, Lee HG, et al. Molecular pathogenesis of Alzheimer’s disease: reductionist versus expansionist approaches. Int J Mol Sci. 2009; 10:1386–406.
Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology. 2013; 80:1778–83.
Prince M, Bryce R, Albanese E, et al. The global prevalence of dementia: a systematic review and meta-analysis. Alzheimers Dement. 2013; 9:63–75.
Sosa-Ortiz AL, Acosta-Castillo I, Prince MJ. Epidemiology of dementias and Alzheimer’s disease. Arch Med Res. 2012; 43:600–8.
Braak H, Braak E. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol. 1991; 1:213–6.
Hyman BT, Phelps CH, Beach TG, et al. National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers Dement. 2012; 8:1–13.
Larson EB, Yaffe K, Langa KM. New insights into the dementia epidemic. N Engl J Med. 2013; 369:2275–7.
Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. J Am Med Assoc. 1997; 278:1349–56.
van Duijn CM, Clayton D, Chandra V, et al. Familial aggregation of Alzheimer’s disease and related disorders: a collaborative re-analysis of case-control studies. Int J Epidemiol. 1991; 20(Suppl 2):S13–20.
Guerreiro R, Wojtas A, Bras J, et al. TREM2 variants in Alzheimer’s disease. N Engl J Med. 2013; 368:117–27.
Helzner EP, Luchsinger JA, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol. 2009; 66:343–8.
Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002; 360:7–22.
Honig LS, Kukull W, Mayeux R. Atherosclerosis and AD: analysis of data from the US National Alzheimer’s Coordinating Center. Neurology. 2005; 64:494–500.
Költringer P, Langsteger W, Eber O. Dose-dependent hemorheological effects and microcirculatory modifications following intravenous administration of Ginkgo biloba special extract EGb 761. Clin Hemorheol. 1995; 15:649–56.
Whitmer RA, Sidney S, Selby J, et al. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology. 2005; 64:277–81.
Whitmer RA. The epidemiology of adiposity and dementia. Curr Alzheimer Res. 2007; 4:117–22.
Martin-Jiménez C, Gaitán-Vaca D, Echeverria V, et al. Relationship between obesity, Alzheimer’s disease and Parkinson’s disease: an astrocentric view. Mol Neurobiol. (2016 Oct 28. [Epub ahead of print] Review) . doi: doi: https://doi.org/10.1007/s12035-016-0193-8. PubMed PMID: 27796748 .
Profenno L, Porsteinsson A, Faraone S. Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders. Biol Psychiatry. 2010; 67:505–12.
Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med. 2009; 39:3–11.
Chouliaras L, Sierksma AS, Kenis G, et al. Erratum: gene-environment interaction research and transgenic mouse models of Alzheimer’s disease. Int J Alzheimers Dis. 2011; 2010:356862.
Gray L, Anderson L, Dublin S, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med. 2015; 175:401–7.
Gomm W, von Holt K, Thomé F, et al. Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol. 2016; 73:410–6.
Richardson J, Roy A, Shalat S, et al. Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol. 2014; 71:284–90.
Pringsheim T, Jette N, Frolkis A, Steeves TD. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord. 2014; 29:1583–90.
Noyce J, Bestwick P, Silveira-Moriyama L, et al. Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann Neurol. 2012; 72:893–901.
Jakes R, Spillantini G, Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 1994; 345:27–32.
Hansen C, Angot E, Bergström L, et al. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest. 2011; 121:715–25.
Houlden H, Singleton B. The genetics and neuropathology of Parkinson’s disease. Acta Neuropathol. 2012; 124:325–38.
Perfeito R, Cunha-Oliveira T, Rego AC. Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease – resemblance to the effect of amphetamine drugs of abuse. Free Radic Biol Med. 2013; 62:186–201.
Arena G, Valente EM. PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease. J Pathol. 2017; 241:251–63.
Zhang CW, Hang L, Yao TP, Lim KL. Parkin regulation and neurodegenerative disorders. Front Aging Neurosci. 2016; 7:248.
Michiorri S, Gelmetti V, Giarda E, et al. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ. 2010; 17:962–74.
Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013; 19:983–97.
Deng H, Liang H, Jankovic J. F-box only protein 7 gene in parkinsonian-pyramidal disease. JAMA Neurol. 2013; 70:20–4.
Lan AP, Chen J, Zhao Y, et al. mTOR signaling in Parkinson’s disease. Neuromolecular Med. 2017; 19:1–10.
Chen L, Xu B, Liu L, et al. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells. Lab Invest. 2010; 90:762–73.
Choi KC, Kim SH, Ha JY, et al. A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem. 2010; 112:366–76.
Ma T, Hoeffer CA, Capetillo-Zarate E, et al. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer’s disease. PLoS One. 2010; 5:e12845.
Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006; 441:885–9.
Ravikumar B, Duden R, Rubensztein D. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet. 2002; 11:1107–17.
Ozcelik S, Fraser G, Castets P, et al. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS One. 2013; 8:e62459.
Orr ME, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer’s disease pathology. Neurobiol Aging. 2014; 35:1233–42.
Maiti P, Manna J, Veleri S, Frautschy S. Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin. Biomed Res Int. 2014; 2014:495091. doi: doi: https://doi.org/10.1155/2014/495091. Epub 2014 Oct 19 .
Costa LG, Garrick JM, Roquè PJ, Pellacan C. Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxid Med Cell Longev. 2016; 2016:2986796. doi: doi: https://doi.org/10.1155/2016/2986796. Epub 2016 Jan 24 .
Nizzari M, Venezia V, Repetto E, et al. Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling. J Biol Chem. 2007; 282:13833–44.
Detrait E, Danis B, Lamberty Y, Foerch P. Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice. Neurochem Int. 2014; 72:10–3.
Nilsson P, Loganathan K, Sekiguchi M, et al. Aβ secretion and plaque formation depend on autophagy. Cell Rep. 2013; 5:61–9.
Yu H, Cuervo M, Kumar A, et al. Macroautophagy – a novel β-amyloid peptide-generating pathway activated in Alzheimer’s disease. J Cell Biol. 2005; 171:87–98.
Zheng L, Terman A, Hallbeck M, et al. Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. Autophagy. 2011; 7:1528–45.
Birch AM, Katsouri L, Sastre M. Modulation of inflammation in transgenic models of Alzheimer’s disease. J Neuroinflammation. 2014; 11:25.
Jack CR Jr, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013; 12:207–16.
Ashe KH, Aguzzi A. Prions, prionoids and pathogenic proteins in Alzheimer disease. Prion. 2013; 7:55–9.
Jiang T, Zhang D, Chen Q, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. 2016; 105:196–206.
Lin T, Beal F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006; 443:787–95.
Cardoso M, Santos S, Swerdlow H, Oliveira R. Functional mitochondria are required for amyloid β-mediated neurotoxicity. FASEB J. 2001; 15:1439–41.
Ghavami S, Shojaei S, Yeganeh B, et al. Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog Neurobiol. 2014; 112:24–49.
Chiti F, Dobson C. Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem. 2006; 75:333–66.
Reynolds A, Laurie C, Moseley RL, Gendelman HE. Oxidative stress and the pathogenesis of neurodegenerative disorders. Int Rev Neurobiol. 2007; 82:297–325.
Chang S, ran Ma T, Miranda D, et al. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci. USA. 2005; 102:18694–9.
Maezawa I, Maeda N, Montine J, Montine KS. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. J Neuroinflammation. 2006; 3:10.
Manzoni C, Mamais A, Roosen A, et al. mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Sci Rep. 2016; 6:35106.
Hu Q, Wang G. Mitochondrial dysfunction in Parkinson’s disease. Transl Neurodegener. 2016; 5:14.
Zhou Q, Chen B, Wang X, et al. Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways. Sci Rep. 2016; 6:32206.
Zhu Z, Yan J, Jiang W, et al. Arctigenin effectively ameliorates memory impairment in Alzheimer’s disease model mice targeting both β-amyloid production and clearance. J Neurosci. 2013; 33:13138–49.
Lin K, Chen D, Chuang C, et al. Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. Int J Mol Sci. 2014; 15:1625–46.
Peng K, Tao Y, Zhang J, et al. Resveratrol regulates mitochondrial biogenesis and fission/fusion to attenuate rotenone-induced neurotoxicity. Oxid Med Cell Longev. 2016; 2016:6705621. doi: 10.1155/2016/6705621. Epub 2015 Dec 6.
Csiszár A, Csiszar A, Pinto J, et al. Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats. J Gerontol A Biol Sci Med Sci. 2015; 70:303–13.
Sarkar S, Perlstein E, Imarisio S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nat Chem Biol. 2007; 3:331–8.
Li W, Zhu S, Li J, et al. EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem Pharmacol. 2011; 81:1152–63.
Zeng Y, Zhang J, Zhu Y, et al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer’s disease. J Neurochem. 2015; 133:38–52.
Xu P, Li Z, Wang H, et al. Triptolide inhibited cytotoxicity of differentiated PC12 cells induced by amyloid-β25–35 via the autophagy pathway. PLoS One. 2015; 10:e0142719.
Zhang J, Wang J, Xu J, et al. Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget. 2016; 7:75659–71.
Suganthy N, Devi KP, Nabavi SF, et al. Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions. Biomed Pharmacother. 2016; 84:892–908.
Fukui K, Masuda A, Hosono A, et al. Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice. Free Radic Res. 2014; 48:649–58.
Sasazawa Y, Sato N, Umezawa K, Simizu S. Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy. J Biol Chem. 2015; 290:6168–78.
Hsu Y, Tseng Y, Lo Y. Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. Toxicol Appl Pharmacol. 2013; 272:787–96.
Rigacci S, Miceli C, Nediani C, et al. Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight. Oncotarget. 2015; 6:35344–57.
Abuznait AH, Qosa H, Busnena BA, et al. Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci. 2013; 4:973–82.
Sheu SJ, Chen JL, Bee YS, et al. Differential autophagic effects of vital dyes in retinal pigment epithelial ARPE-19 and photoreceptor 661W cells. PLoS One. 2017; 12:e0174736.
Martin L, Pan Y, Price A, et al. Parkinson’s disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci. 2006; 26:41–50.
Hunn B, Cragg S, Bolam J, et al. Impaired intracellular trafficking defines early Parkinson’s disease. Trends Neurosci. 2015; 38:178–88.
Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol. 2008; 183:795–803.
Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell. 2012; 22:320–33.
Zhou ZD, Sathiyamoorthy S, Angeles DC, Tan EK. Linking F-box protein 7 and Parkin to neuronal degeneration in Parkinson’s disease (PD). Mol Brain. 2016; 9:41.
Jiang J, Jiang J, Zuo Y, Gu Z. Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease. Int J Mol Med. 2013; 31:825–32.
Le W, Wu J, Tang Y. Protective microglia and their regulation in Parkinson’s disease. Front Mol Neurosci. 2016; 9:89.
Wang M, Cheng X, Jin M, et al. TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells. Exp Neurol. 2015; 271:112–21.
Singh M, Jensen M, Lerman A, et al. Effect of low-dose rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study. J Frailty Aging. 2016; 5:204–7.
Tai H, Wang Z, Gong H, et al. Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence. Autophagy. 2017; 13:99–113.
Nikiforov M. TOR-inhibitors as gero-suppressors. Aging (Albany NY). 2015; 7:1030–1.
Kaeberlein M. The biology of aging: citizen scientists and their pets as a bridge between research on model organisms and human subjects. Vet Pathol. 2016; 53:291–8.
Deng C, Tao R, Yu SZ, Jin H. Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner. Mol Med Rep. 2012; 5:847–51.
Jazwa A, Rojo AI, Innamorato NG, et al. Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. Antioxid Redox Signal. 2011; 14:2347–60.
Garcia-Alloza M, Borrelli LA, Rozkalne A, et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007; 102:1095–104.
Zhang X, Hu J, Zhong L, et al. Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice. Neuropharmacology. 2016; 108:179–92.
Lee M, McGeer EG, McGeer PL. Quercetin, not caffeine, is a major neuroprotective component in coffee. Neurobiol Aging. 2016; 46:113–23.
Grimm MO, Stahlmann CP, Mett J, et al. Vitamin E: curse or benefit in Alzheimer’s disease? A systematic investigation of the impact of α-, γ- and δ-tocopherol on Aβ generation and degradation in neuroblastoma cells. J Nutr Health Aging. 2015; 19:646–56.
Chang CF, Lee YC, Lee KH, et al. Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS. J Biomed Sci. 2016; 23:72.
Zhu ZG, Sun MX, Zhang WL, et al. The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials. Neurol Sci. 2017; 38:215–24.